免疫原
Synthesized peptide derived from human BHE22 AA range: 243-293
特异性
This antibody detects endogenous levels of BHE22 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016],
功能
function:Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,tissue specificity:Brain-specific, with the highest expression in the cerebellum.,
基因名称（Gene Name）
BHLHE22 BHLHB5 TNRC20
组织表达
Brain-specific, with the highest expression in the cerebellum.
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