免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
IMP2L Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011],
功能
disease:Defects in IMMP2L may be a cause of Gilles de la Tourette syndrome (GTS) [MIM:137580]. GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities.,function:Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.,similarity:Belongs to the peptidase S26 family.,similarity:Belongs to the peptidase S26 family. IMP2 subfamily.,subunit:Heterodimer of 2 subunits, IMMPL1 and IMMPL2.,tissue specificity:Expressed in all tissues tested except adult liver and lung.,
蛋白名称
Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein)
细胞定位
Mitochondrion inner membrane ; Single-pass membrane protein .
组织表达
Expressed in all tissues tested except adult liver and lung.
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