免疫原
Synthesized peptide derived from human GPAA1 AA range: 111-161
特异性
This antibody detects endogenous levels of GPAA1 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008],
功能
function:Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,sequence caution:Erroneous prediction from an unspliced cDNA.,subunit:Forms a complex with PIGK/GPI8, PIGT, PIGU and PIGS.,tissue specificity:Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.,
基因名称（Gene Name）
GPAA1 GAA1
Fields
>>Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;>>Metabolic pathways
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达
Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.
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