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APLP-1 Polyclonal Antibody

说明书

BYab-12849

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
72kD
免疫原
Synthesized peptide derived from APLP-1 . at AA range: 360-440
特异性
APLP-1 Polyclonal Antibody detects endogenous levels of APLP-1 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
功能
domain:The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.,function:May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.,function:The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.,miscellaneous:Binds zinc and copper in the extracellular domain. Zinc-
基因名称(Gene Name)
APLP1
蛋白名称
Amyloid-like protein 1
简称
APLP-1
其他名称
APLP1; Amyloid-like protein 1; APLP; APLP-1
Fields
人基因ID
333
人蛋白质序列数据库
P51693
小鼠基因ID
11803
小鼠蛋白质序列数据库
Q03157
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cell membrane; Single-pass type I membrane protein.; [C30]: Cytoplasm. C-terminally processed in the Golgi complex.
组织表达
Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
储存(Storage)
-20°C/1 year

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APLP-1 Polyclonal Antibody

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