免疫原
Synthesized peptide derived from human GGT2 AA range: 89-139
特异性
This antibody detects endogenous levels of GGT2 at Human
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.166% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008],
功能
catalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,disease:Defects in GGT1 are a cause of glutathionuria [MIM:231950]; also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.,function:Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.,function:Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.,miscellaneous:Corresponds to the light chain of other
其他名称
Gamma-glutamyltranspeptidase 2 (GGT 2) (EC 2.3.2.2) (Gamma-glutamyltransferase 2) (Glutathione hydrolase 2) (EC 3.4.19.13) [Cleaved into: Gamma-glutamyltranspeptidase 2 heavy chain; Gamma-glutamyltranspeptidase 2 light chain]
细胞定位
Cytoplasm, perinuclear region . Endoplasmic reticulum . Co-localizes with calnexin in the endoplasmic reticulum.
组织表达
Highly expressed in fetal and adult kidney and liver.
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