免疫原
Synthesized peptide derived from part region of human protein
特异性
YTHD2 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene
功能
similarity:Contains 1 YTH domain.,
基因名称（Gene Name）
YTHDF2 HGRG8
蛋白名称
YTH domain family protein 2 (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2)
细胞定位
Cytoplasm, cytosol . Cytoplasm, P-body . Cytoplasm, Stress granule . Nucleus . Localizes to the cytosol and relocates to the nucleus following heat shock stress (PubMed:26458103). Can partition into different structures: into P-bodies in unstressed cells, and into stress granules during stress (PubMed:31292544). .
组织表达
Highly expressed in induced pluripotent stem cells (iPSCs) and down-regulated during neural differentiation.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
