免疫原
Synthesized peptide derived from human EXOSX AA range: 391-441
特异性
This antibody detects endogenous levels of EXOSX at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
disease:Antibodies against PM/SCL are found in patients with polymyositis and/or scleroderma.,function:Part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Could be an exonuclease (By similarity). Mediates the association of MTR4, C1D and MPP6 wth the exosome and this complex is required for the maturation of 5.8S rRNA. Required for nucleolar localization of C1D.,similarity:Contains 1 3'-5' exonuclease domain.,similarity:Contains 1 HRDC domain.,subunit:Component of the exosome multienzyme ribonuclease com
基因名称（Gene Name）
EXOSC10 PMSCL PMSCL2 RRP6
细胞定位
Cytoplasm. Nucleus, nucleolus. Nucleus. Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
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