分子量(DA)
60kd,unspecial bands( 65kd,105kd,130kd)in Hela and HCT116 cell.
免疫原
The antiserum was produced against synthesized peptide derived from human USP30. AA range:31-80
特异性
USP30 Polyclonal Antibody detects endogenous levels of USP30 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景(Background)
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008],
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:May participate in the maintenance of mitochondrial morphology.,similarity:Belongs to the peptidase C19 family.,tissue specificity:Expressed in skeletal muscle, pancreas, liver and kidney.,
蛋白名称
Ubiquitin carboxyl-terminal hydrolase 30
其他名称
USP30; Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme 30; Ubiquitin thioesterase 30; Ubiquitin-specific-processing protease 30; Ub-specific protease 30
Fields
>>Mitophagy - animal
细胞定位
Mitochondrion outer membrane .
组织表达
Expressed in skeletal muscle, pancreas, liver and kidney.