免疫原
The antiserum was produced against synthesized peptide derived from human AOX1. AA range:521-570
特异性
AOX1 Polyclonal Antibody detects endogenous levels of AOX1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008],
功能
catalytic activity:An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2).,caution:Was originally (PubMed:8248161) thought to be a xanthine dehydrogenase.,cofactor:Binds 2 2Fe-2S clusters.,cofactor:FAD.,cofactor:Molybdopterin.,similarity:Belongs to the xanthine dehydrogenase family.,similarity:Contains 1 2Fe-2S ferredoxin-type domain.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Homodimer.,tissue specificity:Abundant in liver, lower levels in lung, skeletal muscle, pancreas. Undetected in heart, brain and kidney.,
其他名称
AOX1; AO; Aldehyde oxidase
Fields
>>Valine, leucine and isoleucine degradation;>>Tyrosine metabolism;>>Tryptophan metabolism;>>Vitamin B6 metabolism;>>Nicotinate and nicotinamide metabolism;>>Retinol metabolism;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>JAK-STAT signaling pathway
组织表达
Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
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