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FOXP1 Polyclonal Antibody

说明书

BYab-02231

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
75kD
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP1. AA range:628-677
特异性
FOXP1 Polyclonal Antibody detects endogenous levels of FOXP1 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
功能
alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.,domain:The leucine-zipper is required for dimerization and transcriptional repression.,function:Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1.,
基因名称(Gene Name)
FOXP1
蛋白名称
Forkhead box protein P1
简称
FOXP1
其他名称
FOXP1; HSPC215; Forkhead box protein P1
Fields
>>MicroRNAs in cancer
人基因ID
27086
人蛋白质序列数据库
Q9H334
小鼠基因ID
108655
小鼠蛋白质序列数据库
P58462
大鼠基因ID
297480
大鼠蛋白质序列数据库
Q498D1
细胞定位
Nucleus . Not found in the nucleolus. .
组织表达
Isoform 8 is specifically expressed in embryonic stem cells.
储存(Storage)
-20°C/1 year

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FOXP1 Polyclonal Antibody

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