免疫原
The antiserum was produced against synthesized peptide derived from human LRRC41. AA range:391-440
特异性
LRRC41 Polyclonal Antibody detects endogenous levels of LRRC41 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
caution:It is uncertain whether Met-1 or Met-23 is the initiator.,domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,function:Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translation N-terminally extended.,similarity:Contains 7 LRR (leucine-rich) repeats.,subunit:Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.,
功能
caution:It is uncertain whether Met-1 or Met-23 is the initiator.,domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,function:Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translation N-terminally extended.,similarity:Contains 7 LRR (leucine-rich) repeats.,subunit:Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.,
蛋白名称
Leucine-rich repeat-containing protein 41
其他名称
LRRC41; MUF1; PP7759; Leucine-rich repeat-containing protein 41; Protein Muf1
细胞定位
nucleus,cytoplasm,membrane,
组织表达
Brain,Endometrium,Epithelium,Pancreas,Testis,Tonsil,
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