免疫原
Synthesized peptide derived from human SELK
特异性
This antibody detects endogenous levels of SELK at Human, Mouse,Rat
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins . Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function . Plays a role in protection of cells from ER stress-induced apoptosis . Protects cells from oxidative stress when overexpressed in cardiomyocytes .
基因名称(Gene Name)
SELK HSPC030 HSPC297
蛋白名称
Selenoprotein K (SelK)
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Cell membrane ; Single-pass membrane protein . Probably mainly localized in the ER. .
组织表达
Highly expressed in heart.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)