免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human EDN1. AA range:131-180
特异性
ET-1 Monoclonal Antibody detects endogenous levels of ET-1 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
功能
function:Endothelins are endothelium-derived vasoconstrictor peptides.,online information:Endothelin entry,similarity:Belongs to the endothelin/sarafotoxin family.,tissue specificity:Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.,
其他名称
EDN1; Endothelin-1; Preproendothelin-1; PPET1
Fields
>>cAMP signaling pathway;>>HIF-1 signaling pathway;>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction;>>TNF signaling pathway;>>Melanogenesis;>>Renin secretion;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Pathways in cancer;>>Hypertrophic cardiomyopathy;>>Fluid shear stress and atherosclerosis
组织表达
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.
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