免疫原
The antiserum was produced against synthesized peptide derived from human PGD. AA range:71-120
特异性
PGD Monoclonal Antibody detects endogenous levels of PGD protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],
功能
catalytic activity:6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.,similarity:Belongs to the 6-phosphogluconate dehydrogenase family.,subunit:Homodimer.,
蛋白名称
6-phosphogluconate dehydrogenase decarboxylating
其他名称
PGD; PGDH; 6-phosphogluconate dehydrogenase; decarboxylating
Fields
>>Pentose phosphate pathway;>>Glutathione metabolism;>>Metabolic pathways;>>Carbon metabolism
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