免疫原
Synthesized peptide derived from human TMEM119
特异性
This antibody detects endogenous levels of TMEM119 at Human, Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts . May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
基因名称（Gene Name）
TMEM119 PSEC0199 UNQ731/PRO1415
蛋白名称
Transmembrane protein 119
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Endoplasmic reticulum membrane .
组织表达
Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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