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DMRT1 rabbit pAb

说明书

BYab-17892

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB
分子量(DA)
41kD
免疫原
Synthesized peptide derived from human DMRT1. AA range:330-373
特异性
This antibody detects endogenous levels of DMRT1 at Human, Mouse
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
功能
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play
基因名称(Gene Name)
DMRT1 DMT1
蛋白名称
Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
简称
其他名称
Fields
人基因ID
1761
人蛋白质序列数据库
Q9Y5R6
小鼠基因ID
50796
小鼠蛋白质序列数据库
Q9QZ59
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus .
组织表达
Testis-specific. Expressed in prostate cancer (at protein level).
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)

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DMRT1 rabbit pAb

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