免疫原
Synthesized peptide derived from AKR1A1 . at AA range: 250-330
特异性
AKR1A1 Polyclonal Antibody detects endogenous levels of AKR1A1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011],
功能
catalytic activity:An alcohol + NADP(+) = an aldehyde + NADPH.,function:Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,
蛋白名称
Alcohol dehydrogenase [NADP(+)]
其他名称
AKR1A1; ALDR1; ALR; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Aldo-keto reductase family 1 member A1
Fields
>>Glycolysis / Gluconeogenesis;>>Pentose and glucuronate interconversions;>>Ascorbate and aldarate metabolism;>>Glycerolipid metabolism;>>Pyruvate metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Chemical carcinogenesis - reactive oxygen species
细胞定位
Cytoplasm, cytosol . Apical cell membrane .
组织表达
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
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