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Integrin α5 Monoclonal Antibody

说明书

BYab-16836

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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产品简介>

宿主
反应性
应用
WB;IHC;IF;FCM;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human Integrin α5 expressed in E. Coli.
特异性
Integrin α5 Monoclonal Antibody detects endogenous levels of Integrin α5 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
integrin subunit alpha 5(ITGA5) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],
功能
function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,
基因名称(Gene Name)
ITGA5
蛋白名称
Integrin alpha-5
简称
Integrin α5
其他名称
ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD antigen CD49e
Fields
>>Phagosome;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Hematopoietic cell lineage;>>Regulation of actin cytoskeleton;>>Bacterial invasion of epithelial cells;>>Shigellosis;>>Pertussis;>>Yersinia infection;>>Human papillomavirus infection;>>Herpes simplex virus 1 infection;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
人基因ID
3678
人蛋白质序列数据库
P08648
小鼠基因ID
小鼠蛋白质序列数据库
P11688
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .
组织表达
Liver,Placenta,
储存(Storage)
-20°C/1 year

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Integrin α5 Monoclonal Antibody

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