免疫原
Purified recombinant fragment of Fibulin-2 (aa180-440) expressed in E. Coli.
特异性
Fibulin-2 Monoclonal Antibody detects endogenous levels of Fibulin-2 protein.
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
背景(Background)
This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
功能
developmental stage:Widely expressed during embryonic development. Primarily detected within the neuropithelium, spinal ganglia and peripheral nerves.,function:Its binding to fibronectin and some other ligands is calcium dependent.,similarity:Belongs to the fibulin family.,similarity:Contains 11 EGF-like domains.,similarity:Contains 3 anaphylatoxin-like domains.,subunit:Homotrimer; disulfide-linked. Interacts with LAMA2.,tissue specificity:Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.,
其他名称
FBLN2; Fibulin-2; FIBL-2
细胞定位
Secreted, extracellular space, extracellular matrix.
组织表达
Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.