免疫原
Synthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894)
特异性
This antibody detects endogenous levels of Human,Mouse ITGA5 (heavy chain, Cleaved-Arg894, protein was cleaved amino acid sequence between 894-895 )
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,
功能
cell motion, cell-substrate junction assembly, cell adhesion, heterophilic cell adhesion, leukocyte adhesion, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, behavior, learning or memory, memory,response to wounding, cell-cell adhesion, cell migration, biological adhesion, cell adhesion mediated by integrin, cell-cell adhesion mediated by integrin, cell junction assembly, cell junction organization, wound healing, spreading of epidermal cells, wound healing, cell motility, neurological system process, cognition, localization of cell,
基因名称（Gene Name）
ITGA5 FNRA
蛋白名称
ITGA5 (heavy chain, Cleaved-Arg894)
其他名称
Integrin alpha-5 (CD49 antigen-like family member E;Fibronectin receptor subunit alpha;Integrin alpha-F;VLA-5;CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
Fields
>>Phagosome;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Hematopoietic cell lineage;>>Regulation of actin cytoskeleton;>>Bacterial invasion of epithelial cells;>>Shigellosis;>>Pertussis;>>Yersinia infection;>>Human papillomavirus infection;>>Herpes simplex virus 1 infection;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy
细胞定位
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .
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