免疫原
The antiserum was produced against synthesized peptide derived from human MFNG. AA range:61-110
特异性
Manic Fringe Polyclonal Antibody detects endogenous levels of Manic Fringe protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009],
功能
catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,function:Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.,online information:Beta-1,3-N-acetylglucosaminyltransferase manic fringe,online information:GlycoGene database,similarity:Belongs to the glycosyltransferase 31 family.,
蛋白名称
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
其他名称
MFNG; Beta-1; 3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Fields
>>Other types of O-glycan biosynthesis;>>Notch signaling pathway;>>Human papillomavirus infection
细胞定位
Golgi apparatus membrane ; Single-pass type II membrane protein .
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
