免疫原
Synthesized peptide derived from human Mart-1/Melan-A
特异性
This antibody detects endogenous levels of human Mart-1/Melan-A. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section
来源
Mouse, Monoclonal/IgG2b, Kappa
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:300-500. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
功能
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
基因名称（Gene Name）
MLANA MART1
其他名称
Melanoma antigen recognized by T-cells 1 (MART-1;Antigen LB39-AA;Antigen SK29-AA;Protein Melan-A)
细胞定位
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
组织表达
Expression is restricted to melanoma and melanocyte cell lines and retina.
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