免疫原
The antiserum was produced against synthesized peptide derived from human NARF. AA range:262-311
特异性
NARF Polyclonal Antibody detects endogenous levels of NARF protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It
功能
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the NARF family.,subunit:Interacts with LMNA and binds to the farnesylated C-terminal domain.,tissue specificity:Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.,
蛋白名称
Nuclear prelamin A recognition factor
其他名称
NARF; Nuclear prelamin A recognition factor; Iron-only hydrogenase-like protein 2; IOP2
组织表达
Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.
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