免疫原
Synthetic peptide from human protein at AA range: 131-180
特异性
The antibody detects endogenous BMP-1
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008],
功能
catalytic activity:Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.,cofactor:Binds 1 zinc ion per subunit.,enzyme regulation:Activity is increased by the procollagen C-endopeptidase enhancer protein.,function:Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD).,similarity:Belongs to the peptidase M12A family.,similarity:Contains 2 EGF-like domains.,similarity:Contains 5 CUB domains.,tissue specificity:Ubiquitous.,
基因名称（Gene Name）
BMP1 PCOLC
蛋白名称
Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
其他名称
Bone morphogenetic protein 1 (BMP-1;EC 3.4.24.19;Mammalian tolloid protein;mTld;Procollagen C-proteinase;PCP)
细胞定位
Golgi apparatus, trans-Golgi network . Secreted, extracellular space, extracellular matrix . Secreted . Co-localizes with POSTN in the Golgi. .; [Isoform BMP1-3]: Secreted .
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