免疫原
The antiserum was produced against synthesized peptide derived from human CKI-epsilon. AA range:276-325
特异性
Casein Kinase Iε Polyclonal Antibody detects endogenous levels of Casein Kinase Iε protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
casein kinase 1 epsilon(CSNK1E) Homo sapiens The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.,induction:Down-regulated during granulocytic differentiation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Component of the circadian core oscillator, which includes the CRY pro
蛋白名称
Casein kinase I isoform epsilon
其他名称
CSNK1E; Casein kinase I isoform epsilon; CKI-epsilon; CKIe
Fields
>>FoxO signaling pathway;>>Wnt signaling pathway;>>Hedgehog signaling pathway;>>Hippo signaling pathway;>>Hippo signaling pathway - multiple species;>>Circadian rhythm;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Cytoplasm . Nucleus .
组织表达
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
