免疫原
The antiserum was produced against synthesized peptide derived from human FCGR2A. AA range:241-290
特异性
CD32-A Polyclonal Antibody detects endogenous levels of CD32-A protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Fc fragment of IgG receptor IIa(FCGR2A) Homo sapiens This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008],
功能
function:Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function.,tissue specificity:Found on monocytes, neutrophils and eosinophil platelets.,
蛋白名称
Low affinity immunoglobulin gamma Fc region receptor II-a
其他名称
FCGR2A; CD32; FCG2; FCGR2A1; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD antigen CD32
Fields
>>Phagosome;>>Osteoclast differentiation;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Fc gamma R-mediated phagocytosis;>>Pathogenic Escherichia coli infection;>>Yersinia infection;>>Leishmaniasis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Coronavirus disease - COVID-19;>>Systemic lupus erythematosus
细胞定位
Cell membrane ; Single-pass type I membrane protein .
组织表达
Found on monocytes, neutrophils and eosinophil platelets.
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