免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human GFER. AA range:51-100
特异性
ALR Polyclonal Antibody detects endogenous levels of ALR protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008],
功能
catalytic activity:4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.,cofactor:FAD.,function:FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.,similarity:Contains 1 ERV/ALR sulfhydryl oxidase domain.,subunit:Homodimer.,
蛋白名称
FAD-linked sulfhydryl oxidase ALR
其他名称
GFER; ALR; HERV1; HPO; FAD-linked sulfhydryl oxidase ALR; Augmenter of liver regeneration; hERV1; Hepatopoietin
细胞定位
[Isoform 1]: Mitochondrion intermembrane space. Mitochondrion .; [Isoform 2]: Cytoplasm. Secreted.
组织表达
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.
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