免疫原
The antiserum was produced against synthesized peptide derived from human GRM5. AA range:21-70
特异性
mGluR5 Polyclonal Antibody detects endogenous levels of mGluR5 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
glutamate metabotropic receptor 5(GRM5) Homo sapiens This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
功能
function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,
蛋白名称
Metabotropic glutamate receptor 5
其他名称
GRM5; GPRC1E; MGLUR5; Metabotropic glutamate receptor 5; mGluR5
Fields
>>Calcium signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Long-term potentiation;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Alzheimer disease;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Cell membrane ; Multi-pass membrane protein .
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