免疫原
The antiserum was produced against synthesized peptide derived from human ADORA1. AA range:277-326
特异性
Adenosine A1-R Polyclonal Antibody detects endogenous levels of Adenosine A1-R protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008],
功能
function:Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
蛋白名称
Adenosine receptor A1
其他名称
ADORA1; Adenosine receptor A1
Fields
>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Sphingolipid signaling pathway;>>Neuroactive ligand-receptor interaction;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Morphine addiction
细胞定位
Cell membrane ; Multi-pass membrane protein.
组织表达
Brain,Heart,Hippocampus,
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