免疫原
Synthesized peptide derived from human Dab1 (Phospho Tyr220)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Dab1 (Phospho Tyr220)
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
domain:The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.,function:Adapter molecule functioning in neural development. May regulate SIAH1 activity.,PTM:Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.,similarity:Contains 1 PID domain.,subunit:Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1.,
功能
neuron migration, cell motion, cell adhesion, negative regulation of cell adhesion, intracellular signaling cascade, small GTPase mediated signal transduction, cell-cell adhesion, cell migration, regulation of phosphate metabolic process, cell migration in hindbrain, telencephalon development, pallium development, cerebellum development, hindbrain morphogenesis, hindbrain structural organization, cerebellum morphogenesis, cerebellum structural organization,cerebral cortex cell migration, cerebral cortex radially oriented cell migration, cerebral cortex radial glia guided migration, neuronal-glial interaction involved in cerebral cortex radial glia guided migration, cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration, forebrain cell migration, hindbrain radial glia guided cell migration, radial glia guided migration of Purkin
蛋白名称
Dab1 (Phospho Tyr220)
其他名称
DAB1; Disabled homolog 1
Fields
>>Spinocerebellar ataxia
组织表达
Mainly expressed in brain.
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