免疫原
The antiserum was produced against synthesized peptide derived from human DIDO1. AA range:161-210
特异性
Dio-1 Polyclonal Antibody detects endogenous levels of Dio-1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008],
功能
disease:Defects in DIDO1 may be a cause of myeloid neoplasms.,function:Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor.,similarity:Contains 1 PHD-type zinc finger.,similarity:Contains 1 TFIIS central domain.,subcellular location:Translocates to the nucleus after pro-apoptotic stimuli.,tissue specificity:Ubiquitous.,
蛋白名称
Death-inducer obliterator 1
其他名称
DIDO1; C20orf158; DATF1; KIAA0333; Death-inducer obliterator 1; DIO-1; hDido1; Death-associated transcription factor 1; DATF-1
细胞定位
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. .
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