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CHRDL1 Monoclonal Antibody

说明书

BYab-12624

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB
分子量(DA)
免疫原
Purified recombinant human CHRDL1 protein fragments expressed in E.coli.
特异性
CHRDL1 Monoclonal Antibody detects endogenous levels of CHRDL1 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
稀释比例
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
1 mg/ml
背景(Background)
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009],
功能
function:Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.,induction:By hypoxia in retinal pericytes.,similarity:Contains 3 VWFC domains.,tissue specificity:Expressed in retinal pericytes.,
基因名称(Gene Name)
CHRDL1
蛋白名称
Chordin-like protein 1
简称
CHRDL1
其他名称
CHRDL1; NRLN1; Chordin-like protein 1; Neuralin-1; Neurogenesin-1; Ventroptin
Fields
人基因ID
91851
人蛋白质序列数据库
Q9BU40
小鼠基因ID
小鼠蛋白质序列数据库
Q920C1
大鼠基因ID
363455
大鼠蛋白质序列数据库
Q76LD0
细胞定位
Secreted .
组织表达
Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.
储存(Storage)
-20°C/1 year

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CHRDL1 Monoclonal Antibody

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