免疫原
Synthesized peptide derived from human ROMO1 AA range: 17-67
特异性
This antibody detects endogenous levels of ROMO1 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1：50-200. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014],
功能
developmental stage:Expression increases in senescent cells.,function:Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence.,induction:By the anticancer drug fluorouracil (5FU).,miscellaneous:Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.,similarity:Belongs to the MGR2 family.,tissue specificity:Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line.,
基因名称（Gene Name）
ROMO1 C20orf52
细胞定位
Mitochondrion inner membrane ; Single-pass membrane protein .
组织表达
Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.
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