免疫原
Synthesized peptide derived from human SYNJ2 AA range: 145-195
特异性
This antibody detects endogenous levels of SYNJ2 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
功能
alternative products:Additional isoforms seem to exist,catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,domain:The C-terminal proline-rich region of isoform 2B2 mediates binding to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.,function:Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.,similarity:Belongs to the synaptojanin family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAC domain.,similarity:In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family.,subcellular location:Predominantly associated with the particulate fractions.,subunit:Binds to GRB2. Isoform 2A binds to SYNJ2BP/
基因名称（Gene Name）
SYNJ2 KIAA0348
Fields
>>Inositol phosphate metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system
细胞定位
Cytoplasm . Cell membrane . Membrane raft . Cell junction, synapse, presynapse . Cytoplasm, cytoskeleton . Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). .
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