免疫原
Synthesized peptide derived from human EMAL4 AA range: 398-448
特异性
This antibody detects endogenous levels of EMAL4 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015],
功能
developmental stage:Strongly overexpressed during mitosis.,function:May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.,similarity:Belongs to the WD repeat EMAP family.,similarity:Contains 9 WD repeats.,
基因名称（Gene Name）
EML4 C2orf2 EMAPL4
Fields
>>Pathways in cancer;>>Non-small cell lung cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center . Midbody . Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis. .
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
