免疫原
Synthesized peptide derived from human CHP3 AA range: 20-70
特异性
This antibody detects endogenous levels of CHP3 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
caution:It is uncertain whether Met-1 or Met-54 is the initiator.,cofactor:Binds calcium.,developmental stage:Strongly up-regulated in K562 cells treated by PMA to promote megakaryocytic differentiation, but not when treated by DMSO to promote granulocytic differentiation or by hemin to promote erythroid differentiation (at protein level).,function:Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with Sodium/hydrogen exchanger 1 (SLC9A1).,tissue specificity:Abundantly expressed in heart.,
基因名称(Gene Name)
TESC CHP3
细胞定位
Nucleus . Cytoplasm . Membrane ; Lipid-anchor . Cell membrane . Cell projection, lamellipodium . Cell projection, ruffle membrane . Colocalizes with SLC9A1 at the plasma membrane. .
组织表达
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.