免疫原
Synthesized peptide derived from human COTL1 AA range: 29-79
特异性
This antibody detects endogenous levels of COTL1 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008],
功能
function:Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization.,similarity:Belongs to the actin-binding proteins ADF family. Coactosin subfamily.,similarity:Contains 1 ADF-H domain.,subunit:Interacts with 5-lipoxygenase (5LO) in a calcium-independent manner.,tissue specificity:Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.,
基因名称（Gene Name）
COTL1 CLP
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Nucleus .
组织表达
Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
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