免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human TRAP1. AA range:481-530
特异性
The antibody detects endogenous HSP 75
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
功能
function:Chaperone that expresses an ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subunit:Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1.,tissue specificity:Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.,
基因名称（Gene Name）
TRAP1 HSP75
蛋白名称
Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)
其他名称
Heat shock protein 75 kDa, mitochondrial (HSP 75;TNFR-associated protein 1;Tumor necrosis factor type 1 receptor-associated protein;TRAP-1)
Fields
>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Mitochondrion . Mitochondrion inner membrane . Mitochondrion matrix .
组织表达
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
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