免疫原
Synthesized peptide derived from human Shc3 (Phospho-Tyr424)
特异性
This antibody detects endogenous levels of Shc3 (Phospho-Tyr424) at Human, Mouse,Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.198% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,
基因名称（Gene Name）
SHC3 NSHC SHCC
蛋白名称
Shc3 (Phospho-Tyr424)
其他名称
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Chemokine signaling pathway;>>Phospholipase D signaling pathway;>>Focal adhesion;>>Natural killer cell mediated cytotoxicity;>>Neurotrophin signaling pathway;>>Insulin signaling pathway;>>Estrogen signaling pathway;>>Prolactin signaling pathway;>>Relaxin signaling pathway;>>Growth hormone synthesis, secretion and action;>>Alcoholism;>>Bacterial invasion of epithelial cells;>>Glioma;>>Chronic myeloid leukemia;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer
细胞定位
cytosol,plasma membrane,
组织表达
Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
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