免疫原
Synthesized peptide derived from human TRAIP AA range: 399-449
特异性
This antibody detects endogenous levels of TRAIP at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008],
功能
function:Inhibits activation of NF-kappa-B mediated by TNF.,similarity:Contains 1 RING-type zinc finger.,subunit:Binds TRAF1 and TRAF2 and is part of the receptor-TRAF signaling complex (By similarity). Interacts with CYLD.,
基因名称（Gene Name）
TRAIP RNF206 TRIP
细胞定位
Nucleus, nucleoplasm . Nucleus, nucleolus . Chromosome . Cytoplasm. Cytoplasm, perinuclear region . In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:26595769). Localizes to DNA damage sites in response to replication stress (PubMed:26781088, PubMed:26595769, PubMed:26711499). .
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