免疫原
Synthesized peptide derived from human protein . at AA range: 690-770
特异性
CO5 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq,
功能
disease:Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections.,disease:Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis.,function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.,function:Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases v
基因名称（Gene Name）
C5 CPAMD4
蛋白名称
Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]
Fields
>>Neuroactive ligand-receptor interaction;>>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Alcoholic liver disease;>>Prion disease;>>Pertussis;>>Staphylococcus aureus infection;>>Herpes simplex virus 1 infection;>>Coronavirus disease - COVID-19;>>Systemic lupus erythematosus
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
