免疫原
Synthesized peptide derived from human CRTAP AA range: 65-115
特异性
This antibody detects endogenous levels of CRTAP at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008],
功能
disease:Defects in CRTAP are the cause of osteogenesis imperfecta type 2B (OI-2B) [MIM:610854]. OI-2B is an autosomal recessive form of perinatal lethal OI. This form is designated OI-2B to distinguish it from the autosomal dominant form OI-2A.,disease:Defects in CRTAP are the cause of osteogenesis imperfecta type 7 (OI-7) [MIM:610682]. OI is a connective tissue disorder characterized by bone fragility and low bone mass. OI-7 is an autosomal recessive form of OI.,similarity:Belongs to the CRTAP/No55 family.,tissue specificity:Found in articular chondrocytes. Expressed in a variety of tissues.,
基因名称（Gene Name）
CRTAP CASP
细胞定位
Secreted, extracellular space, extracellular matrix .
组织表达
Found in articular chondrocytes. Expressed in a variety of tissues.
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