免疫原
Synthesized peptide derived from human LYRM4 AA range: 30-80
特异性
This antibody detects endogenous levels of LYRM4 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1：50-200. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016],
功能
function:May be involved in mitochondrial iron-sulfur protein biosynthesis.,miscellaneous:Reduction of LYRM4 levels by siRNA increases the total iron content, and reduces cytosolic and mitochondrial aconitase activities and NFS1 protein levels.,pathway:Cofactor biosynthesis; iron-sulfur cluster biosynthesis.,similarity:Belongs to the complex I LYR family.,subunit:Interacts with FXN. Interaction is increased by nickel. Interaction is inhibited by calcium, magnesium, manganese, copper, cobalt, zinc, and iron. Forms a complex with the cytosolic/nuclear form of NFS1. The complex increased the stability of NFS1.,tissue specificity:Reduced mRNA levels in Friedreich ataxia (FA) patients.,
基因名称（Gene Name）
LYRM4 C6orf149 ISD11 CGI-203
细胞定位
Mitochondrion. Nucleus.
组织表达
Reduced mRNA levels in Friedreich ataxia patients.
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