免疫原
Synthesized peptide derived from human IKZF5 AA range: 210-260
特异性
This antibody detects endogenous levels of IKZF5 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002],
功能
domain:C-terminal zinc fingers mediate homodimerization.,domain:The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.,function:DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.,miscellaneous:'Pegasus' was the winged horse in Greek mythology.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Self-associates and interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.,tissue specificity:Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K562. Highly expressed in THP-1 and Mo7e-IL3 cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.,
基因名称（Gene Name）
IKZF5 ZNFN1A5
组织表达
Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
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