免疫原
Synthesized peptide derived from human DYH12 AA range: 565-615
特异性
This antibody detects endogenous levels of DYH12 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1：50-200. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
caution:Although related to the dynein heavy chain family, it is much shorter than the other members of the family and lacks essential conserved regions. Its function as dynein heavy chain is therefore unsure.,caution:Was originally derived from a readthrough transcript including ASB14 and DNAH12. DNHD2 was thought to be a distinct gene.,domain:Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two
基因名称（Gene Name）
DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19
Fields
>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Cytoplasm, cytoskeleton, cilium axoneme .
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