免疫原
Synthesized peptide derived from human CSTN2 AA range: 494-544
特异性
This antibody detects endogenous levels of CSTN2 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.235% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
domain:Binds synaptic Ca(2+) with its cytoplasmic domain.,function:May modulate calcium-mediated postsynaptic signals.,PTM:Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1.,similarity:Contains 2 cadherin domains.,subcellular location:Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.,tissue specificity:Restricted to the bra
基因名称（Gene Name）
CLSTN2 CS2
其他名称
Calsyntenin-2 (Alcadein-gamma) (Alc-gamma)
细胞定位
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane . Golgi apparatus membrane . Cell junction, synapse, postsynapse . Cell projection, dendrite . Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. .
组织表达
Restricted to the brain.
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