免疫原
Synthesized peptide derived from human protein . at AA range: 340-420
特异性
SSR3 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
功能
function:Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.,PTM:Phosphorylated. Phosphorylation increases upon somatostatin binding.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Internalized into endoplasmic vesicles upon somatostatin-stimulation.,tissue specificity:Brain, pituitary and pancreas.,
蛋白名称
Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SSR-28)
Fields
>>Neuroactive ligand-receptor interaction;>>Growth hormone synthesis, secretion and action
细胞定位
Cell membrane ; Multi-pass membrane protein . Internalized into endoplasmic vesicles upon somatostatin-stimulation. .
组织表达
Brain, pituitary and pancreas.
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