免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
AGTR2 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010],
功能
function:Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MTUS1.,tissue specificity:In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine.,
蛋白名称
Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2)
Fields
>>Neuroactive ligand-receptor interaction;>>Adrenergic signaling in cardiomyocytes;>>Renin-angiotensin system
细胞定位
Cell membrane; Multi-pass membrane protein.
组织表达
In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.
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