免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
B2MG Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014],
功能
disease:Defects in B2M are the cause of hypercatabolic hypoproteinemia [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.,function:Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.,online information:Beta-2-microglobulin entry,PTM:Glycation of Ile-21 is observed in long-term hemodialysis patients.,similarity:Belongs to the beta-2-microglobulin family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,
基因名称（Gene Name）
B2M CDABP0092 HDCMA22P
蛋白名称
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Fields
>>Antigen processing and presentation;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection
细胞定位
Secreted . Cell surface . Detected in serum and urine (PubMed:1336137, PubMed:7554280). .; (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553). .
组织表达
Dendritic cell,Eye,Leukemia,Peripheral blood,Skin,Trachea,Urine,
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