免疫原
Synthesized peptide derived from human protein . at AA range: 30-110
特异性
TRML1 Polyclonal Antibody detects endogenous levels of protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012],
功能
function:Cell surface receptor that may play a role in the innate and adaptive immune response.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subcellular location:Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.,subunit:When phosphorylated, interacts with PTPN6 (By similarity). When phosphorylated, interacts with PTPN11.,tissue specificity:Detected in platelets, monocytic leukemia and in T-cell leukemia.,
基因名称（Gene Name）
TREML1 TLT1 UNQ1825/PRO3438
蛋白名称
Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).
组织表达
Detected in platelets, monocytic leukemia and in T-cell leukemia.
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